CRYPTOCHROME mediates behavioral executive choice in response to UV light.

نویسندگان

  • Lisa S Baik
  • Keri J Fogle
  • Logan Roberts
  • Alexis M Galschiodt
  • Joshua A Chevez
  • Yocelyn Recinos
  • Vinh Nguy
  • Todd C Holmes
چکیده

Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 114 4  شماره 

صفحات  -

تاریخ انتشار 2017